DEDD spells death to caspase substrates
نویسندگان
چکیده
منابع مشابه
Caspase substrates and inhibitors.
Caspases are proteases at the heart of networks that govern apoptosis and inflammation. The past decade has seen huge leaps in understanding the biology and chemistry of the caspases, largely through the development of synthetic substrates and inhibitors. Such agents are used to define the role of caspases in transmitting life and death signals, in imaging caspases in situ and in vivo, and in d...
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The CD95 signaling pathway comprises proteins that contain one or two death effector domains (DED), such as FADD/Mort1 or caspase-8. Here we describe a novel 37 kDa protein, DEDD, that contains an N-terminal DED. DEDD is highly conserved between human and mouse (98. 7% identity) and is ubiquitously expressed. Overexpression of DEDD in 293T cells induced weak apoptosis, mainly through its DED by...
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In This Issue In This Issue ROCK and Rho will never Dia irectional migration of a cell requires both lamellipodia formation at the leading edge and actomyosin contraction within the tail. New results from Tsuji et al. (page 819) indicate that Rho may mediate both tasks, and that these two arms of Rho signaling are antagonistic. Rho signaling is known to mediate the formation of stress fibers, s...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2002
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb1586iti1